Multi-Pronged Treatment May Improve Survival for Mesothelioma Patients

Thursday, July 30, 2009

Patients with stage I through III pleural mesothelioma may prolong their lives by combating the cancer with a multi-pronged treatment approach. A new study in the Journal of Clinical Oncology states that the survival rate for patients with stage I – III pleural mesothelioma may improve by using a battery of different forms of treatment, including chemotherapy prior to surgery.

Mesothelioma is a rare cancer closely associated with exposure to asbestos, often many decades ago. Microscopic asbestos particles are inhaled and lodge in the lungs.

Patients with stage I – III pleura mesothelioma have cancer limited to one side of the chest so doctors may be able to remove the cancer surgically. In some patients, with stage III mesotheloioma, the cancer may have spread to the lymph nodes.

Researchers report they began the treatment of 77 patients with pleural mesothelioma by administering chemotherapy before surgery using the medications Alimta and Platinol with the aim of first reducing the size of the cancer. The group of patients included with and without cancer that had spread to the lymph nodes.

In three patients, the chemotherapy knocked back the cancer to the extent there were no clinical signs of cancer remaining, though that doesn’t mean the patients are cured of malignant mesothelioma. Microscopic cancer cells may remain undetected.

Fifty-four patients then underwent surgery to remove the diseased lung, the second phase of the multi-pronged approach. Forty patients then received radiation therapy, the third phase of the treatment.

The median survival rate for the entire group was 17 months, but those who underwent all three rounds of treatment had a two-year survival rate of 61 percent, the researchers said.

The researchers involved in the study concluded it produced reasonable long-term survival results.

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posted by Wade Rawlins at 11:37 AM
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Survey Finds Most Korean Schools Have Asbestos

Investigators in South Korea have found asbestos is 99 percent of the schools examined by the Education Ministry. To allay public concerns about asbestos, the ministry has been conducting a full-scale inspection of all schools across the nation.

Of 3,158 schools inspected to date, 3,138 contained asbestos, The Korea Herald, an English language newspaper reports. The material, which was widely used in construction materials and insulation, can cause serious illnesses if the microscopic asbestos particles become airborne and are inhaled.

Rep. Kim Choon-jin of the Democratic Party, who belongs to the National Assembly’s Education, Science and Technology Committee, said through a spokesman that he will work to rid schools of the asbestos hazard.

Korea Herald

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posted by Wade Rawlins at 11:32 AM
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Bill to Address Asbestos Advances in Israel

Tuesday, July 28, 2009

A bill to address asbestos in a comprehensive way in Israel received a key committee endorsement. The Ministerial Committee on Legislation approved the bill, meaning that it will have the support of the coalition when it goes to the floor of the Knesset, the Israeli parliament, for a vote.

The bill lays out guidelines for working with asbestos and its removal and includes funds for cleanup and treatment of crumbling asbestos, The Jerusalem Post reports.

The city of Nahariya and surrounding area on the northern coast of Israel have one of the highest concentrations of people with mesothelioma in the world. For 45 years, Nahariya was home to an asbestos plant that produced asbestos cement until it was shut down in 1997. Asbestos is no longer made nor imported into Israel. Mesothelioma, a rare form of cancer associated with asbestos, typically develops several decades after exposure.

There were about 600 cases in Israel of people getting sick from asbestos exposure, according to the Organization for Environment and Life in Nahariya.

“The bill is a product of a more than 10-year-old public battle to raise awareness of the danger of asbestos,” Orit Reich, found and director of the Organization for Environment and Life told The Jerusalem Post.

Jerusalem Post story

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posted by Wade Rawlins at 4:46 PM
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Iron Range Mesothelioma Study Underway

Monday, July 27th, one month after the initial planning meeting, University of Minnesota health researchers began sending letters to both current and former taconite workers, and their families, of Minnesota's Taconite Iron Range mine. The University is enlisting them in a wide-ranging study of mesothelioma, a rare cancer caused by exposure to asbestos.

The research is being conducted to determine why so many Iron Range workers have been diagnosed, or are dying, from mesothelioma. To date there has been no link between mesothelioma and taconite. However, 52 workers at the mine have been diagnosed with the rare cancer.

A university spokeswoman said the first batch of thousands of letters have been sent to those selected, regardless of their health status, inviting them to participate in the screening program.

$4.9 million was funded by the Legislature last year for the five-year study.


University of Minnesota Researchers Contact Taconite Workers

Iron Range Meeting to Plan Mesothelioma Study

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posted by Nancy Meredith at 12:10 PM
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Brother and Sister Skydive for Mesothelioma Research

Monday, July 27, 2009

Paul and Claire Rawlinson from the UK will skydive in memory of their father and to raise money for the Mick Knighton Mesothelioma Research Fund (MKMRF), reports the North-West Evening News.

Paul credits his sister with the idea of a organizing a sponsored skydive. While she's not into participating in extreme sports, he said his sister wanted to do something out of the ordinary to show their commitment to the cause. Paul will fall 3,500 feet in a solo jump and his sister will fall 14,000 feet in a tandem jump. They hope to raise ₤2,000 which is over $3,200 in U. S. currency.

Their father died at the age of 64 of mesothelioma, the deadliest form of lung cancer.

MKMRF raises money to improve awareness about mesothelioma, to fund research for treatment, and to provide support to the people who suffer from this deadly disease.

UK Siblings Skydive for Mesothelioma

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posted by Nancy Meredith at 8:29 AM
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Families Warned of Asbestos Detected in Sumas River

Friday, July 24, 2009

Federal environmental investigators in Washington State have found significant levels of naturally-occurring asbestos in Sumas River downstream of Swift Creek.

The asbestos comes from a massive landslide on Sumas Mountain that deposits up to 120,000 cubic yards of asbestos-laden sediment into Swift Creek a year. The latest sampling revealed asbestos and several metals in water, bank sediments and flood deposits at higher concentrations in Sumas River than in previous samples of dredged material from Swift Creek. The concentrations ranged up to 27 percent asbestos along the Sumas riverbank.

“These asbestos levels deserve close attention,” said Dan Opalski, director of EPA’s Superfund Cleanup Office in Seattle. “The new data will enable agencies to make important health recommendations so local families can make informed decisions to protect themselves.”

Asbestos is a naturally occurring mineral that is made up of thin fibers. Inhaling the microscopic asbestos fibers can increase the chance of developing asbestos-related diseases such as mesothelioma and lung cancer.

EPA Fact Sheet

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posted by Wade Rawlins at 10:33 AM
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Hyperthermal Chemotherapy Research Shows Promise for Mesothelioma

Thursday, July 23, 2009

The Journal of Biomedicine and Biotechnology reported that when mesothelioma cells are under stress from heat, they respond with an increased production of heat-shock proteins that "rescue them from death." After disappointing expectations with the use of heated (hyperthermal) chemotherapy, researchers have now discovered that suppressing the release of these heat-responsive proteins in mesothelioma cancer cells can improve the effectiveness of the chemotherapeutic agent.

The study concluded that the inhibition of the stress proteins, Hsp40/Hsp70 or Erk1/2 MAPK, might present a new option to increase the success of hyperthermia in mesothelioma. Most malignant mesothelioma cases are diagnosed at advanced stages, and by that point the cases are highly resistant to chemotherapeutic agents and other available treatments.

Currently, there is no known cure for mesothelioma. Malignant mesothelioma is a relatively rare cancer limiting the amount of new research and funding for the cancer. While this research is promising there remains much more testing to be conducted for mesothelioma therapy.

In the article researchers noted that while it had been predicted that the number of cases of mesothelioma will decline after 2010, recent studies indicate the rate of new malignant mesothelioma cases will continue to rise at a high level for another 10–15 years in Europe and in the United States, while in other countries the rate may even further increase.

Mesothelioma cells escape heat stress

Heat treatment for Mesothelioma

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posted by Nancy Meredith at 9:48 PM
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Researchers Suggest Re-evaluating Definition of Asbestos

By Wade Rawlins
The case of a Michigan school librarian suggests that the definition of asbestos should be broadened, researchers say. In a paper published in the July issue of the International Journal of Occupational and Environmental Health, Dr. Michael R. Harbut and colleagues report on treating a 55-year-old woman who suffers from a stabbing chest pain, has scar tissue on her lungs and other symptoms that meet the classic definition of asbestosis. A scarring of the lungs, asbestosis is typically associated with inhaling asbestos fibers.

The woman, whose name the researchers withheld for medical privacy, has been treated at the National Center for Vermiculite and Asbestos-Related Cancers at Karmanos Cancer Institute at Wayne State University in Detroit, Michigan.

She has experienced pain in the right side of her chest for years. It began as soreness and has progressed to a knife-like pain. She had begun requiring narcotics to handle the pain in recent years. She continues to work as a school librarian in the taconite mining region of Michigan.

The researchers say the most likely cause of the woman’s ailments was dust from taconite mining that her father brought home on his clothes from the mine, when she was a child. He worked as a miner from 1962 to 1969.

Taconite is a rock rich in silica that is used in the production of steel and as a road-patch material. It is mined in Michigan and Minnesota.

The United States government doesn’t classify taconite as asbestos or asbestiform material. But it has been associated with asbestos-related diseases.

“The identification of a material which has not been categorized as asbestos, but causes a disease consistent with asbestosis, requires a reevaluation of the definition of asbestos,” said Mark Harbut, M.D., co-director of the National Center for Vermiculite and Asbestos-Related Cancers and his colleagues. “This is especially important within the context of legislative efforts to prohibit the use of asbestos.

The researchers say their findings support previous reports that dusts produced by taconite mining can cause the same health problems as other fibers already defined as asbestos.

Currently, the Minnesota Department of Health is conducting a study of the cause of more than 48 cases of mesothelioma linked with mining in northeastern Minnesota.

The case suggests that the definition of asbestos should be broadened, they say.

“The question is logically asked, ‘What is asbestos?’” the researchers write. “The most honest answer is, ‘A fiber which causes asbestosis.’”

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posted by Wade Rawlins at 10:20 AM
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Walking for Len to Aid Mesothelioma Research

Thursday, July 16, 2009

John Barnes will attempt to walk the 102-mile Cotswald Way in six days in August to raise money for the June Hancock Mesothelioma Research Fund. Barnes, 62, is undertaking the walk in memory of Graham “Len” Hutton, a retired British policy officer, who died of mesothelioma last year.

“I am hoping my walk will not only increase the awareness of mesothelioma, an asbestos related disease, but also give some of Len’s friends a chance to remember him,” Barnes told Stroud News & Journal in England.

Hutton, 66, served for 30 years as a police officer in London and Gloucestershire. After retiring in 1991, he managed recreation centers. He died in December 2008, six months after diagnosis.

Barnes will walk the trail that passes through a number of picturesque villages from Aug. 26-31. The June Hancock Mesothelioma Research Fund, established after June Hancock’s death in 1997, support high quality research and assists with many patients information seminars.

The Challenge

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posted by Wade Rawlins at 1:55 PM
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Owner of Asbestos Mine, DOJ Reach Settlement Over Contamination

Tuesday, July 14, 2009

By WADE RAWLINS
The former owner of the largest chrysotile asbestos mine and mill in the U.S. has reached a legal settlement with the U.S. Department of Justice to address contamination caused by the former operation.

Under terms of the consent decree, G-I Holdings Inc., formerly known as GAF Corp., will take steps immediately to fence and secure the 1,673-acre abandoned mine and mill site near Lowell, Vermont.

The site has two towering piles of mine and mill waste that are eroding and polluting downstream surface waters, say attorneys with the Department of Justice.

The piles also attract hikers, rock collectors and ATV enthusiasts and may expose people who visit the site to particles of airborne asbestos, Justice officials say. Inhaling asbestos fibers can cause serious respiratory problems and forms of cancer.

G-I Holdings will provide onsite surveillance and will monitor air emissions from the piles and conduct dust suppression if necessary and provide support to EPA and Vermont for future monitoring. The work will be carried out over eight years and G-I will spend up to $7.75 million.

G-I, which has been under bankruptcy protection since 2001, will reimburse the federal government and Vermont a portion of the estimated $300 million for past and future clean-up costs and off site contamination. G-I will pay up to $25.8 million of the cleanup costs. The company also will pay $850,000 for damages to local wetlands and streams.

“The cornerstone of this settlement is that G-I is responsible for completing extensive work at the Vermont Asbestos Group Mine Site, focusing on site security, air monitoring and investigating and sampling certain mine tailings,” John C. Cruden, acting assistant attorney general for the Justice Department’s Environment and Natural Resources Division said in a statement. “G-I will also pay for its share of cleanup costs for this site and nine other contaminated sites around the country.”

The federal government sued G-I in 2008, asking the court to order the company to take immediate action to address pollution that could pose an imminent threat to public health.

Headquartered in Wayne, New Jersey, G-I Holdings and its subsidiary Building Materials Corporation of America make roofing materials such as flashing, vents and shingles. The company has operated under bankruptcy protection since 2001.

The Vermont site is the most significant of 13 contaminated industrial sites covered by the settlement. G-I will contribute $104,615 as its share of cleanup costs to resolve federal claims where its predecessors disposed of hazardous waste.

In addition, the federal government has up to 10 years to bring claims for cleanup costs and environmental damage at three related heavily-contaminated industrial sites in New York and New Jersey —the GAF Chemical site, the LCP Chemicals Inc Superfund site and the Diamond Alkali Superfund site – referred to collectively as the Linden sites.

The consent decree was filed in the U.S. Bankruptcy Court in New Jersey and is subject to a 30-day public comment period and approval by the federal court.

Chrysotile asbestos is one of two general types of asbestos and the most common found in products in the United States. For example, the asbestos fibers detected in the samples taken at the World Trade Center site were chrysotile asbestos.

U.S. Department of Justice Release

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posted by Your Attorney at 10:39 PM
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British Group Calls for Urgent Asbestos Audit of Schools

The head of the British Safety Council said that 16 teachers die each year of asbestos-related illnesses and urged the government to conduct a nationwide effort to find and remove asbestos from schools. “It is unacceptable that the UK, in 2009, has not yet undertaken a national audit of asbestos in schools; has not comprehensively assessed the risks that teachers and pupils in each and every school face,” said Brian Nimick, chief executive of the British Safety Council, an independent non-profit that promotes health and safety issues.

Breathing microscopic fibers of asbestos which was used for decades in insulation, roof tiles and other building materials can lead to respiratory problems and forms of cancer including mesothelioma.

 Nimick said that there had been 228 asbestos-related deaths among teachers in the United Kingdom over the last 14 years—an average of 16 a year. In 2009, he said more than 4,000 people would die of cancers related to asbestos exposure, making it the leading cause of workplace deaths in the United Kingdom

 Nimick said the government has not allocated sufficient money to make asbestos removal a priority or even to assess the risks to teachers and pupils in every school.

 “Without these actions, the tragedy of asbestos in schools will be left to fester and continue to kill the lifeblood of our society,” he said. “Teachers and pupils will continue to live with the deadly legacy of having once worked or studied in a school containing asbestos.”

Read British Safety Council Release

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posted by Wade Rawlins at 1:09 PM
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School Building Evacuated Due to Asbestos Concern

The Humanities Building at Western Washington University in Bellingham was evacuated Monday because of a possible release of asbestos during renovation work.

A contractor doing renovation work removed a piece of asbestos-contaminated ceiling on Monday and did not properly bag or seal it before removing it from the building, The Bellingham Herald reported. That may have spread asbestos fibers  to the rest of the building. Inhaling microscopic asbestos fibers can cause respiratory problems and forms of cancer.

Students and staff were evacuated and classes canceled in the building as a precaution while cleanup contractors assess the situation.

More Details

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posted by Wade Rawlins at 1:00 PM
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Australia Study Reflects Legacy of Asbestos Use

Monday, July 13, 2009

New cases of mesothelioma in Australia will continue increasing until around 2017, a new report predicts. The report by Safe Work Australia, which develops national policy on occupational health and safety issues, said the number of new cases of mesothelioma diagnosed annually in the nation down under has been rising dramatically since at least 1982, the first year of complete national data.

Mesothelioma is a cancer of the lining of the lungs or abdomen closely linked to asbestos exposure. The number of new cases increased from 156 in 1982 to 597 in 2005, the report said.

The general demographic pattern revealed in the Australia study is similar to that in a new U.S. study, with four out of five mesothelioma deaths among men and mostly older men at that. Use of asbestos peaked in both the United States and Australia in the 1970s and has since been regulated and sharply reduced.

But because of the long lag time of 20 to 40 years from exposure to development of mesothelioma, the number of new cases will keep rising for some additional years, reflecting the legacy of extensive asbestos use in earlier decades, researchers say.

Researchers with the National Institute for Occupational Safety and Health in the current issue of JAMA (Journal of the American Medical Association) report that the overall annual deaths from mesothelioma in the U.S. are still increasing, though the rate as a portion of the population has been stable in recent years. More than 18,000 deaths from mesothelioma were reported in the U.S from 1999 to 2005, researchers reported.

Although asbestos is no longer mined in the United States, it is still imported and a substantial amount of asbestos in buildings eventually must be removed. An estimated 1.3 million American construction workers and general industry workers are exposed to asbestos, researchers say, underscoring the need for efforts to minimize exposure.

Asbestos exposure in the Australian workplace is now regulated and minimized, so new cases of mesothelioma should eventually start going down. But the number of new cases is projected to increase through much of the next decade – longer than in the U.S. American researchers project deaths should peak here around 2010.

The Australian report provides national, state and territory data of the number and incidence rate of new cases and deaths from mesothelioma in Australia.

“It is exciting to be part of the important task of harmonizing occupational health and safety laws and … across Australia,” Tom Phillips, chairman of the Safe Work Australia Council said in a statement. The council agreed to specifications for maintenance of an Australian Mesothelioma Registry to be a comprehensive source of data on asbestos exposure.

The overall number of deaths in Australia generally increased over the period from 1997 to 2006, according to data from the Australian Institute of Health and Welfare. In 2006, there were 486 deaths attributed to mesothelioma. More than 80 percent of the deaths were men, and three-quarters were over age 65, very much like the profile of newly diagnosed cases.

Overall, the age-adjusted death rate in Australia due to mesothelioma was 23 deaths per million population. In comparison, the annual U.S. rate is 14 deaths per million.

Mesothelioma of the pleura, a cancer affecting the protective lining of the lung and chest cavity, was by far the most common form of mesothelioma diagnosed in Australia, involving 94 percent of the cases. Mesothelioma of the peritoneal, the abdominal lining, was reported in about 5 percent of cases.

Consumption of asbestos for manufacturing peaked in Australia in about 1975. Over 60 percent of all production and 90 percent of consumption of asbestos occurred in the asbestos cement manufacturing industry.
The most populous states, New South Wales, Victoria and Queensland, generally had the most new cases of mesothelioma from 2001 to 2005, the report said.

New South Wales, which has by far the most cases, was the first state in Australia to mine asbestos. Half the houses built in New South Wales from the end of World War II through 1954 were built of asbestos cement.

Similarly, in the U.S., the most populous states generally had the highest number of deaths. California, the largest state in population with an estimated 36 million people, led in mesothelioma-related deaths with 1,779 from 1999-2005.

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posted by Wade Rawlins at 12:09 PM
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Federal Officials Collecting Soil Samples at Washington Site To Test For Asbestos

Wednesday, July 8, 2009

Federal environmental investigators wearing white hazmat suits and respirators have begun collecting soil samples in Spokane, Washington to retest a former vermiculite insulation manufacturing site, a Spokane newspaper reports.

For 22 years, Vermiculite Northwest produced Zonolite, an asbestos-tainted attic insulation from vermiculite ore shipped by rail from Libby, Montana, The Spokesman-Review reported.

The U.S. Environmental, which found only trace amounts of asbestos near the former factory site in 2000 and 2001, decided to conduct additional testing after the agency declared a public health emergency in Libby, where contamination from a now-shuttered vermiculite mine has been cited in the deaths of more than 200 people. Breathing asbestos fibers can cause respiratory problems and forms of cancer decades after exposure.

The EPA is testing soils at nine residences near the site of the former plant, which W.R. Grace & Co. closed in 1973.

Washington Soil Tested For Asbestos

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posted by Your Attorney at 4:08 PM
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Report: Australian Mesothelioma Deaths To Continue Rising

A new Australian government report predicts that incidence of mesothelioma in that country will keep rising until at least 2017. The report by Safe Work Australia, which develops national policy on occupational health and safety issues, said the number of new cases of mesothelioma diagnosed annually in the nation down under has been rising dramatically since 1982, when national data first became available.

The number of new cases increased from 156 in 1982 to 597 in 2005, the report said.

Asbestos exposure in the workplace is now regulated and minimized in Australia. But because mesothelioma, a cancer closely linked to asbestos exposure, can take 20 to 40 years to appear, the number of new cases is projected to continue increasing.

The overall number of deaths from mesothelioma generally increased over the period from 1997 to 2006, the report said citing data collected by the Australian Institute of Health and Welfare. In 2006, there were 486 deaths attributed to mesothelioma. More than 80 percent of the deaths across the time period were men.

Mesothelioma of the pleura, a cancer affecting the protective lining of the lung and chest cavity, was by the most common form of mesothelioma diagnosed in Australia, involving 94 percent of the cases.

Mesothelioma of the peritoneal, the abdominal lining, was reported in about 5 percent of cases.

Australian Mesothelioma Report

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posted by Your Attorney at 4:04 PM
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Asbestos Information For Real Estate Agents

When dealing with the public in the housing market it is important that real estate agents know and present the facts regarding asbestos products. Disclosure guidelines require the seller of residential property to provide the buyer with a disclosure statement containing information on the presence or prior removal of asbestos.

Asbestos is a naturally occurring mineral, with very strong, heat resistant properties, making it appealing for use in many products. Asbestos has been used in the manufacture of heating and domestic water systems including pipes, boilers, gaskets, and tanks, spray-on insulation for fireproofing and acoustical purposes, vinyl and linoleum flooring, and drop-in ceiling tiles. Asbestos-containing materials (ACM) are also found in exterior building materials, such as on shingles and roofing products.

Removal of Asbestos for Renovation Projects
Although some localities have local ordinances that require landlords to maintain asbestos in rental properties in good condition, there are no state or federal laws that require the removal of asbestos containing materials from either commercial or residential properties.

Because of the dangers posed from handling asbestos, the real estate agent should advise their clients that if there is asbestos in their home or business, they should not attempt to remove it on their own. Many companies across the United States specialize in the removal of this hazardous substance and should be contracted for the work.

Asbestos Products That Are Safe To Handle
There are some limited ACMs that are safe for a homeowner to handle without requiring support from a specialized asbestos removal company. Improper removal could result in costly health and clean-up costs to the homeowner. Therefore, real estate agents should advise their clients to contact their local Environmental Protection Agency for further information before undertaking any housing renovation project. If a contractor is contacted for the work, they must be a certified asbestos-abatement company.

Items Safe to Remove
  • Asbestos containing siding in single family homes only.

  • Asbestos-containing roofing materials, mastics, glues, cements, sealants,coatings, and adhesives

  • Intact asbestos-containing floor tiles.

Be sure to advise buyers that the asbestos waste generated by these activities must be disposed in a landfill licensed to accept non-friable asbestos.

NOTE: In all cases, asbestos containing pipe and boiler insulation in residential properties must be removed by licensed asbestos abatement contractors.

Supporting The Client
The client and their family’s safety is a real estate agent's priority, and because asbestos is a potential liability they should err on the side of caution. The following checklist can be used as a reminder of the obligations to a real estate client.

Checklist for Asbestos Safety

  • Ensure that the appropriate the disclosure statements are provided,

  • Remind clients to hire only licensed asbestos abatement contractors to remove asbestos containing materials,

  • Advise clients to contact the appropriate companies and agencies before attempting to remove asbestos containing siding, roofing or floor tiles,

  • Real estate agents should contact their local asbestos removal companies and agencies if they have any questions on state or federal asbestos regulations.

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posted by Nancy Meredith at 3:29 PM
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Riders on 'Breathtaking' Journey to Raise Awareness of Asbestos-Related Disease

Thursday, July 2, 2009

A team of cyclists is near finishing a 1,200-mile ride from Glasgow, Scotland to Southampton, England to raise awareness of the plight of asbestos-related cancer victims and promote the idea of a national research center.

Since late June, the three riders have been riding through some of the areas most affected by mesothelioma to highlight the asbestos-related cancer’s deadly legacy. The Southhampton and Portsmouth areas have been particularly hard hit because of shipbuilding and railway industries.

The team, which includes two British lawyers who specialize in asbestos disease cases, is seeking to call attention to the fact that there isn’t dedicated government funding in Britain for asbestos cancer research, even though it's a leading cause of work-related deaths. The cyclists will finish the ride by July 5.

Here’s their blog of the journey: http://breathtakingjourney.blogspot.com/.

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posted by Your Attorney at 8:51 AM
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Wade Rawlins is a former environmental reporter with the Raleigh News & Observer.

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