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Multi-Pronged Treatment May Improve Survival for Mesothelioma Patients

Thursday, July 30th, 2009

Patients with stage I through III pleural mesothelioma may prolong their lives by combating the cancer with a multi-pronged treatment approach. A new study in the Journal of Clinical Oncology states that the survival rate for patients with stage I – III pleural mesothelioma may improve by using a battery of different forms of treatment, including chemotherapy prior to surgery.

Mesothelioma is a rare cancer closely associated with exposure to asbestos, often many decades ago. Microscopic asbestos particles are inhaled and lodge in the lungs.

Patients with stage I – III pleura mesothelioma have cancer limited to one side of the chest so doctors may be able to remove the cancer surgically. In some patients, with stage III mesotheloioma, the cancer may have spread to the lymph nodes.

Researchers report they began the treatment of 77 patients with pleural mesothelioma by administering chemotherapy before surgery using the medications Alimta and Platinol with the aim of first reducing the size of the cancer. The group of patients included with and without cancer that had spread to the lymph nodes.

In three patients, the chemotherapy knocked back the cancer to the extent there were no clinical signs of cancer remaining, though that doesn’t mean the patients are cured of malignant mesothelioma. Microscopic cancer cells may remain undetected.

Fifty-four patients then underwent surgery to remove the diseased lung, the second phase of the multi-pronged approach. Forty patients then received radiation therapy, the third phase of the treatment.

The median survival rate for the entire group was 17 months, but those who underwent all three rounds of treatment had a two-year survival rate of 61 percent, the researchers said.

The researchers involved in the study concluded it produced reasonable long-term survival results.

Survey Finds Most Korean Schools Have Asbestos

Thursday, July 30th, 2009

Investigators in South Korea have found asbestos is 99 percent of the schools examined by the Education Ministry. To allay public concerns about asbestos, the ministry has been conducting a full-scale inspection of all schools across the nation.

Of 3,158 schools inspected to date, 3,138 contained asbestos, The Korea Herald, an English language newspaper reports. The material, which was widely used in construction materials and insulation, can cause serious illnesses if the microscopic asbestos particles become airborne and are inhaled.

Rep. Kim Choon-jin of the Democratic Party, who belongs to the National Assembly’s Education, Science and Technology Committee, said through a spokesman that he will work to rid schools of the asbestos hazard.

Korea Herald

Bill to Address Asbestos Advances in Israel

Tuesday, July 28th, 2009

A bill to address asbestos in a comprehensive way in Israel received a key committee endorsement. The Ministerial Committee on Legislation approved the bill, meaning that it will have the support of the coalition when it goes to the floor of the Knesset, the Israeli parliament, for a vote.

The bill lays out guidelines for working with asbestos and its removal and includes funds for cleanup and treatment of crumbling asbestos, The Jerusalem Post reports.

The city of Nahariya and surrounding area on the northern coast of Israel have one of the highest concentrations of people with mesothelioma in the world. For 45 years, Nahariya was home to an asbestos plant that produced asbestos cement until it was shut down in 1997. Asbestos is no longer made nor imported into Israel. Mesothelioma, a rare form of cancer associated with asbestos, typically develops several decades after exposure.

There were about 600 cases in Israel of people getting sick from asbestos exposure, according to the Organization for Environment and Life in Nahariya.

“The bill is a product of a more than 10-year-old public battle to raise awareness of the danger of asbestos,” Orit Reich, found and director of the Organization for Environment and Life told The Jerusalem Post.

Jerusalem Post story

Iron Range Mesothelioma Study Underway

Tuesday, July 28th, 2009

Monday, July 27th, one month after the initial planning meeting, University of Minnesota health researchers began sending letters to both current and former taconite workers, and their families, of Minnesota’s Taconite Iron Range mine. The University is enlisting them in a wide-ranging study of mesothelioma, a rare cancer caused by exposure to asbestos.

The research is being conducted to determine why so many Iron Range workers have been diagnosed, or are dying, from mesothelioma. To date there has been no link between mesothelioma and taconite. However, 52 workers at the mine have been diagnosed with the rare cancer.

A university spokeswoman said the first batch of thousands of letters have been sent to those selected, regardless of their health status, inviting them to participate in the screening program.

$4.9 million was funded by the Legislature last year for the five-year study.

University of Minnesota Researchers Contact Taconite Workers

Iron Range Meeting to Plan Mesothelioma Study

Brother and Sister Skydive for Mesothelioma Research

Monday, July 27th, 2009

Paul and Claire Rawlinson from the UK will skydive in memory of their father and to raise money for the Mick Knighton Mesothelioma Research Fund (MKMRF), reports the North-West Evening News.

Paul credits his sister with the idea of a organizing a sponsored skydive. While she’s not into participating in extreme sports, he said his sister wanted to do something out of the ordinary to show their commitment to the cause. Paul will fall 3,500 feet in a solo jump and his sister will fall 14,000 feet in a tandem jump. They hope to raise ₤2,000 which is over $3,200 in U. S. currency.

Their father died at the age of 64 of mesothelioma, the deadliest form of lung cancer.

MKMRF raises money to improve awareness about mesothelioma, to fund research for treatment, and to provide support to the people who suffer from this deadly disease.

UK Siblings Skydive for Mesothelioma

Families Warned of Asbestos Detected in Sumas River

Friday, July 24th, 2009

Federal environmental investigators in Washington State have found significant levels of naturally-occurring asbestos in Sumas River downstream of Swift Creek.

The asbestos comes from a massive landslide on Sumas Mountain that deposits up to 120,000 cubic yards of asbestos-laden sediment into Swift Creek a year. The latest sampling revealed asbestos and several metals in water, bank sediments and flood deposits at higher concentrations in Sumas River than in previous samples of dredged material from Swift Creek. The concentrations ranged up to 27 percent asbestos along the Sumas riverbank.

“These asbestos levels deserve close attention,” said Dan Opalski, director of EPA’s Superfund Cleanup Office in Seattle. “The new data will enable agencies to make important health recommendations so local families can make informed decisions to protect themselves.”

Asbestos is a naturally occurring mineral that is made up of thin fibers. Inhaling the microscopic asbestos fibers can increase the chance of developing asbestos-related diseases such as mesothelioma and lung cancer.

EPA Fact Sheet

Hyperthermal Chemotherapy Research Shows Promise for Mesothelioma

Friday, July 24th, 2009
The Journal of Biomedicine and Biotechnology reported that when mesothelioma cells are under stress from heat, they respond with an increased production of heat-shock proteins that “rescue them from death.” After disappointing expectations with the use of heated (hyperthermal) chemotherapy, researchers have now discovered that suppressing the release of these heat-responsive proteins in mesothelioma cancer cells can improve the effectiveness of the chemotherapeutic agent.

The study concluded that the inhibition of the stress proteins, Hsp40/Hsp70 or Erk1/2 MAPK, might present a new option to increase the success of hyperthermia in mesothelioma. Most malignant mesothelioma cases are diagnosed at advanced stages, and by that point the cases are highly resistant to chemotherapeutic agents and other available treatments.

Currently, there is no known cure for mesothelioma. Malignant mesothelioma is a relatively rare cancer limiting the amount of new research and funding for the cancer. While this research is promising there remains much more testing to be conducted for mesothelioma therapy.

In the article researchers noted that while it had been predicted that the number of cases of mesothelioma will decline after 2010, recent studies indicate the rate of new malignant mesothelioma cases will continue to rise at a high level for another 10–15 years in Europe and in the United States, while in other countries the rate may even further increase.

Mesothelioma cells escape heat stress

Heat treatment for Mesothelioma

Researchers Suggest Re-evaluating Definition of Asbestos

Thursday, July 23rd, 2009

By Wade Rawlins
The case of a Michigan school librarian suggests that the definition of asbestos should be broadened, researchers say. In a paper published in the July issue of the International Journal of Occupational and Environmental Health, Dr. Michael R. Harbut and colleagues report on treating a 55-year-old woman who suffers from a stabbing chest pain, has scar tissue on her lungs and other symptoms that meet the classic definition of asbestosis. A scarring of the lungs, asbestosis is typically associated with inhaling asbestos fibers.

The woman, whose name the researchers withheld for medical privacy, has been treated at the National Center for Vermiculite and Asbestos-Related Cancers at Karmanos Cancer Institute at Wayne State University in Detroit, Michigan.

She has experienced pain in the right side of her chest for years. It began as soreness and has progressed to a knife-like pain. She had begun requiring narcotics to handle the pain in recent years. She continues to work as a school librarian in the taconite mining region of Michigan.

The researchers say the most likely cause of the woman’s ailments was dust from taconite mining that her father brought home on his clothes from the mine, when she was a child. He worked as a miner from 1962 to 1969.

Taconite is a rock rich in silica that is used in the production of steel and as a road-patch material. It is mined in Michigan and Minnesota.

The United States government doesn’t classify taconite as asbestos or asbestiform material. But it has been associated with asbestos-related diseases.

“The identification of a material which has not been categorized as asbestos, but causes a disease consistent with asbestosis, requires a reevaluation of the definition of asbestos,” said Mark Harbut, M.D., co-director of the National Center for Vermiculite and Asbestos-Related Cancers and his colleagues. “This is especially important within the context of legislative efforts to prohibit the use of asbestos.

The researchers say their findings support previous reports that dusts produced by taconite mining can cause the same health problems as other fibers already defined as asbestos.

Currently, the Minnesota Department of Health is conducting a study of the cause of more than 48 cases of mesothelioma linked with mining in northeastern Minnesota.

The case suggests that the definition of asbestos should be broadened, they say.

“The question is logically asked, ‘What is asbestos?’” the researchers write. “The most honest answer is, ‘A fiber which causes asbestosis.’”

Walking for Len to Aid Mesothelioma Research

Thursday, July 16th, 2009

John Barnes will attempt to walk the 102-mile Cotswald Way in six days in August to raise money for the June Hancock Mesothelioma Research Fund. Barnes, 62, is undertaking the walk in memory of Graham “Len” Hutton, a retired British policy officer, who died of mesothelioma last year.

“I am hoping my walk will not only increase the awareness of mesothelioma, an asbestos related disease, but also give some of Len’s friends a chance to remember him,” Barnes told Stroud News & Journal in England.

Hutton, 66, served for 30 years as a police officer in London and Gloucestershire. After retiring in 1991, he managed recreation centers. He died in December 2008, six months after diagnosis.

Barnes will walk the trail that passes through a number of picturesque villages from Aug. 26-31. The June Hancock Mesothelioma Research Fund, established after June Hancock’s death in 1997, support high quality research and assists with many patients information seminars.

The Challenge

Owner of Asbestos Mine, DOJ Reach Settlement Over Contamination

Wednesday, July 15th, 2009

By WADE RAWLINS
The former owner of the largest chrysotile asbestos mine and mill in the U.S. has reached a legal settlement with the U.S. Department of Justice to address contamination caused by the former operation.

Under terms of the consent decree, G-I Holdings Inc., formerly known as GAF Corp., will take steps immediately to fence and secure the 1,673-acre abandoned mine and mill site near Lowell, Vermont.

The site has two towering piles of mine and mill waste that are eroding and polluting downstream surface waters, say attorneys with the Department of Justice.

The piles also attract hikers, rock collectors and ATV enthusiasts and may expose people who visit the site to particles of airborne asbestos, Justice officials say. Inhaling asbestos fibers can cause serious respiratory problems and forms of cancer.

G-I Holdings will provide onsite surveillance and will monitor air emissions from the piles and conduct dust suppression if necessary and provide support to EPA and Vermont for future monitoring. The work will be carried out over eight years and G-I will spend up to $7.75 million.

G-I, which has been under bankruptcy protection since 2001, will reimburse the federal government and Vermont a portion of the estimated $300 million for past and future clean-up costs and off site contamination. G-I will pay up to $25.8 million of the cleanup costs. The company also will pay $850,000 for damages to local wetlands and streams.

“The cornerstone of this settlement is that G-I is responsible for completing extensive work at the Vermont Asbestos Group Mine Site, focusing on site security, air monitoring and investigating and sampling certain mine tailings,” John C. Cruden, acting assistant attorney general for the Justice Department’s Environment and Natural Resources Division said in a statement. “G-I will also pay for its share of cleanup costs for this site and nine other contaminated sites around the country.”

The federal government sued G-I in 2008, asking the court to order the company to take immediate action to address pollution that could pose an imminent threat to public health.

Headquartered in Wayne, New Jersey, G-I Holdings and its subsidiary Building Materials Corporation of America make roofing materials such as flashing, vents and shingles. The company has operated under bankruptcy protection since 2001.

The Vermont site is the most significant of 13 contaminated industrial sites covered by the settlement. G-I will contribute $104,615 as its share of cleanup costs to resolve federal claims where its predecessors disposed of hazardous waste.

In addition, the federal government has up to 10 years to bring claims for cleanup costs and environmental damage at three related heavily-contaminated industrial sites in New York and New Jersey —the GAF Chemical site, the LCP Chemicals Inc Superfund site and the Diamond Alkali Superfund site – referred to collectively as the Linden sites.

The consent decree was filed in the U.S. Bankruptcy Court in New Jersey and is subject to a 30-day public comment period and approval by the federal court.

Chrysotile asbestos is one of two general types of asbestos and the most common found in products in the United States. For example, the asbestos fibers detected in the samples taken at the World Trade Center site were chrysotile asbestos.

U.S. Department of Justice Release

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